Rosa Scarpelli
PC34 – Rosa Scarpelli
University Magna Graecia of Catanzaro, Italy
ORCID
rosa.scarpelli@studenti.unicz.it
| Deep Eutectic Solvents (DES) for the Sustainable Extraction of Phytocompounds from Cannabis sativa |
| Scarpelli Rosa1,2, Gualtieri Alessandro1,2, Frisina Marialaura1,2, David Maria Teresa2, Procopio Antonio1,2, Nardi Monica1,2 1 Departement of Health Sciences, University Magna Graecia of Catanzaro, Campus S. Venuta, Viale Europa, Germaneto, 88100 Catanzaro (Italy) 2 “AGreenFood” Research Center, University “Magna Græcia” of Catanzaro, Campus Universitario “S Venuta”, 88100 Catanzaro (Italy) |
| Abstract Cannabidiol (CBD) is one of the most extensively studied phytocannabinoids due to its lack of psychoactive effects and its proven biological properties [1], including anti-inflammatory, anxiolytic and neuroprotective effects. Currently, purified CBD formulations are already usedin the clinical treatment of drug-resistant epilepsy. However, conventionalextraction methods based on organic solvents present issues related to toxicity, flammability and high energy and environmental impact [2]. This study proposes an eco-sustainable extraction of CBD from Cannabis sativa L., based on the use of Deep Eutectic Solvents (DES) [3]. Subsequently,the research focused on the preparation of DES composed directlyof CBD [4] and oleic acid, exploring their potential for pharmaceutical applicationsas innovative systems in the pharmaceutical sector. |
| References [1] Li, H., Liu, Y., Tian, D., Tian, L., Ju, X., Qi, L., Liang, C. Overview of cannabidiol (CBD) and its analogues: Structures, biological activities, and neuroprotective mechanisms in epilepsy and Alzheimer’s disease. Eur. J. Med. Chem., 2020,192, 112163. https://doi.org/10.1016/j.ejmech.2020.112163 [2] Kanyairita, G. G., Mortley, D. G., Boersma, M., Collier, W. E. Comparison of the Efficiency of Deep Eutectic and Organic Solvents in the Extraction of Phytochemicals from Cannabis sativaL.Separations, 2024, 11(4), 106. https://doi.org/10.3390/separations11040106 [3] Scarpelli, R., Bence, R., Cano, N. C. H., Procopio, A., Wunderlin, D., Nardi, M. A review on the use of deep eutectic solvents in protection reactions.Molecules, 2024, 29(4), 818. https://doi.org/10.3390/molecules29040818 [3] Cazzaniga, C. S., Ayres, L. B., Barroso, J., García, C. D. Deep eutectic solvents incorporating cannabinoids: The influence of water on stability. J. Mol. Liq., 2026, 129563. https://doi.org/10.1016/j.molliq.2026.129563 |