{"id":2192,"date":"2026-05-08T13:31:07","date_gmt":"2026-05-08T11:31:07","guid":{"rendered":"https:\/\/sites.unica.it\/pe2026\/?p=2192"},"modified":"2026-05-13T12:53:17","modified_gmt":"2026-05-13T10:53:17","slug":"mihail-lucian-birsa","status":"publish","type":"post","link":"https:\/\/sites.unica.it\/pe2026\/2026\/05\/08\/mihail-lucian-birsa\/","title":{"rendered":"Mihail Lucian Birsa"},"content":{"rendered":"\n
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PC4 – Mihail Lucian Birsa<\/strong><\/p>\n\n\n\n

Department of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, Romania

<\/a>lbirsa@uaic.ro<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

Synthetic Flavonoid – An Alternative Solution to Combat Eskape Pathogens<\/strong><\/td><\/tr>
Mihail Lucian Birsa1<\/sup><\/em>

1<\/sup><\/em> Department of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, Romania
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Abstract<\/strong>
ESKAPE pathogens are considered as global threats to human health. The discovery of new molecules for which these pathogens have not yet developed resistance is a high medical priority [1]. Synthetic flavonoids are good candidates for developing new antimicrobials [2, 3]. Therefore, we report here the potent in vitro antibacterial activity of BrCl-flav (Figure 1), a representative of a new class of synthetic tricyclic flavonoids. Minimum inhibitory\/bactericidal concentration, time kill and biofilm formation assays were employed to evaluate the antibacterial potential of BrCl-flav. The mechanism of action was investigated using fluorescence and scanning electron microscopy. A checkerboard assay was used to study the effect of the tested compound in combination with antibiotics. Our results showed that BrCl-flav displayed important inhibitory activity against all tested clinical isolates, with MICs ranging between 0.24 and 125 \u00b5g\/mL. A total kill effect was recorded after only 1 h of exposing Enterococcus faecium<\/em> cells to BrCl-flav. Additionally, BrCl-flav displayed important biofilm disruption potential against Acinetobacter baumannii<\/em>. Those effects were induced by membrane integrity damage. BrCl-flav expressed synergistic activity in combination with penicillin against a MRSA strain. Based on the potent antibacterial activity, low cytotoxicity and pro-inflammatory effect, BrCl-flav has good potential for developing new effective drugs against ESKAPE pathogens [4].
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Figure 1. <\/strong>The chemical structure of BrCl-flav<\/td><\/tr>
References  <\/strong>
[1] Pendleton, J.N.; Gorman, S.P.; Gilmore, B.F. Clinical relevance of the ESKAPE pathogens. Expert Rev. Anti-Infect. Ther. <\/em>2013<\/strong>, 11<\/em>, 297\u2013308. https:\/\/doi.org\/10.1586\/eri.13.12
[2] Sarbu, L.G.; Bahrin, L.G.; Babii, C.; Stefan, M.; Birsa, M.L. Synthetic flavonoids with antimicrobial activity: A review. J. Appl. Microbiol. <\/em>2019<\/strong>, 127<\/em>, 1282\u20131290. https:\/\/doi.org\/10.1111\/jam.14271
[3] Bahrin, L.G.; Hopf, H.; Jones, P.G.; Sarbu, L.G.; Babii, C.; Mihai, A.C.; Stefan, M.; Birsa, L.M. Antibacterial structure-activity relationship studies of several tricyclic sulfur-containing flavonoids. Beilstein J. Org. Chem. <\/em>2016<\/strong>, 12<\/em>, 1065\u20131071. https:\/\/doi.org\/10.3762\/bjoc.12.100
[4] Moldovan, C.V., Savu, M., Dussert, E., Aboubacar, H., Sarbu, L.G., Matiut, S., Cudennec, B., Krier, F., Ravallec, R., Birsa, M.L., Stefan, M., “Synthetic Flavonoid BrCl-Flav-An Alternative Solution to Combat ESKAPE Pathogens”, Antibiotics (Basel)<\/em>, 11<\/strong>, 1389 (2022). https:\/\/doi.org\/10.3390\/antibiotics11101389<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n

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PC4 – Mihail Lucian Birsa Department of Chemistry, \u201cAlexandru Ioan Cuza\u201d University of Iasi, Romanialbirsa@uaic.ro Synthetic Flavonoid – An Alternative Solution to Combat Eskape Pathogens Mihail Lucian Birsa1 1 Department of Chemistry, \u201cAlexandru Ioan Cuza\u201d University […]<\/p>\n","protected":false},"author":10371,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2192","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2192","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/10371"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=2192"}],"version-history":[{"count":4,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2192\/revisions"}],"predecessor-version":[{"id":2484,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2192\/revisions\/2484"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=2192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=2192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=2192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}