{"id":2101,"date":"2026-05-07T17:26:54","date_gmt":"2026-05-07T15:26:54","guid":{"rendered":"https:\/\/sites.unica.it\/pe2026\/?p=2101"},"modified":"2026-05-08T17:33:15","modified_gmt":"2026-05-08T15:33:15","slug":"jagoda-szkudlarek-2","status":"publish","type":"post","link":"https:\/\/sites.unica.it\/pe2026\/2026\/05\/07\/jagoda-szkudlarek-2\/","title":{"rendered":"Jagoda Szkudlarek"},"content":{"rendered":"\n
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PC37 – Jagoda Szkudlarek<\/strong><\/p>\n\n\n\n

Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, Pozna\u0144, Poland
Doctoral School, Poznan University of Medical Sciences, Pozna\u0144, Poland<\/p>\n\n\n\n

ORCID<\/a><\/strong><\/p>\n\n\n\n

jszkudlarek@ump.edu.pl<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

Cationic Liposomes Co-Loaded With Cannabidiol and Additional Natural Bioactive Compounds for In Vitro Evaluation Against Glioblastoma Multiforme<\/strong><\/strong><\/td><\/tr>
Szkudlarek Jagoda1,2<\/sup>, Piwowarczyk Ludwika1<\/sup>, Krajka-Kuzniak Violetta3<\/sup>, Majchrzak-Celi\u0144ska Aleksandra3<\/sup>, and Jeli\u0144ska Anna1<\/sup><\/em>

1<\/sup><\/em> Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, Rokietnicka 3, 60\u2011803 Pozna\u0144, Poland
2<\/sup><\/em> Doctoral School, Poznan University of Medical Sciences, 70 Bukowska, 60-812 Pozna\u0144, Poland
3<\/sup><\/em> Chair and Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 3 Rokietnicka, 60-806 Pozna\u0144, Poland<\/td><\/tr>
Abstract<\/strong>
Glioblastoma multiforme is a highly aggressive brain tumor associated with poor clinical outcomes. Despite advances in standard therapies, treatment efficacy remains limited, prompting the search for new therapeutic strategies [1]. Natural compounds have emerged as promising candidates due to their diverse biological activities, but their clinical application is often restricted by limited bioavailability [2]. In this setting, nanocarrier-based delivery systems, particularly liposomes, offer an attractive approach by improving drug stability, enhancing bioavailability, and facilitating more effective transport of therapeutic agents to tumor tissue [3]. In this study, cationic liposomes were developed as carriers for cannabidiol (CBD) co-encapsulated with additional natural compounds for in vitro evaluation against glioma cells. The formulations were prepared by the thin-film hydration method, followed by extrusion to obtain more uniform vesicles. Physicochemical characterization included particle size, polydispersity index, and zeta potential measurements. Anticancer activity was assessed in U-138 MG cells using the MTT assay after 24 and 48 h of incubation, with non-cancer cells used as a reference. Liposomal systems showed nanoscale particle size, low polydispersity, and positive zeta potential. In vitro studies demonstrated that co-loaded formulations reduced glioma cell viability more effectively than the empty carrier, particularly after longer incubation. One of the co-loaded formulations showed a stronger antiproliferative effect in U-138 MG cells compared with the other formulation. Overall, cationic liposomes appear to be promising carriers for CBD-based combination therapy in glioblastoma and warrant further investigation.<\/td><\/tr>
References  <\/strong>
[1] Weller, M.; Wen, P.Y.; Chang, S.M.; Dirven, L.; Lim, M.; Monje, M.; Reifenberger, G. Glioma. Nat Rev Dis Primers.<\/em> 2024<\/strong>, 10(1), 33.
[2] O\u017carowski, M.; Karpi\u0144ski, T.M.; Czerny, B.; Kami\u0144ski, A.; Seremak-Mrozikiewicz, A. Plant alkaloids as promising anticancer compounds with blood-brain barrier penetration in the treatment of glioblastoma: in vitro and in vivo models. Molecules<\/em> 2025<\/strong>, 30(7), 1561.
[3] Haseeb, M.; Khan, I.; Kartal, Z.; Mahfooz, S.; Hatiboglu, M.A. Status quo in the liposome-based therapeutic strategies against glioblastoma: \u201ctargeting the tumor and tumor microenvironment\u201d. Int J Mol Sci.<\/em> 2024<\/strong>, 25(20), 11271.<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

PC37 – Jagoda Szkudlarek Poznan University of Medical Sciences, Chair and Department of Pharmaceutical Chemistry, Pozna\u0144, PolandDoctoral School, Poznan University of Medical Sciences, Pozna\u0144, Poland ORCID jszkudlarek@ump.edu.pl Cationic Liposomes Co-Loaded With Cannabidiol and Additional Natural Bioactive […]<\/p>\n","protected":false},"author":10371,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2101","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/10371"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=2101"}],"version-history":[{"count":3,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2101\/revisions"}],"predecessor-version":[{"id":2361,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2101\/revisions\/2361"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=2101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=2101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=2101"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}