![\"\"](\"https:\/\/sites.unica.it\/pe2026\/files\/2026\/05\/Yardimci-Elif.jpeg\")
<\/figure>FPC11 – Elif Yardimci<\/strong><\/p>\n\n\n\n Agri Ibrahim Cecen University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Agri, T\u00fcrkiye Ankara University, Graduate School of Health Science, Ankara, T\u00fcrkiye<\/p>\n\n\n\n LinkedIn<\/strong> <\/a>–<\/strong> ORCID<\/a><\/strong><\/p>\n\n\n\n eyardimci@agri.edu.tr<\/strong><\/p>\n<\/div><\/div>\n\n\n\n <\/p>\n\n\n\n <\/p>\n","protected":false},"excerpt":{"rendered":" FPC11 – Elif Yardimci Agri Ibrahim Cecen University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Agri, T\u00fcrkiye Ankara University, Graduate School of Health Science, Ankara, T\u00fcrkiye LinkedIn – ORCID eyardimci@agri.edu.tr Novel N-Phenylacetamide Derivatives: In Vitro and […]<\/p>\n","protected":false},"author":10371,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2081","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2081","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/10371"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=2081"}],"version-history":[{"count":4,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2081\/revisions"}],"predecessor-version":[{"id":2167,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/2081\/revisions\/2167"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=2081"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=2081"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=2081"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Novel N-Phenylacetamide Derivatives: In Vitro and In Silico Evaluation Against Prostate Cancer<\/strong><\/td><\/tr> Yardimci Elif 1,2<\/sup>, Erzurumlu Yalcin 3<\/sup>, and Yildiz Ilkay 4<\/sup>
<\/em>
1<\/sup> <\/em>Ankara University, Graduate School of Health Science, Ankara, T\u00fcrkiye
2<\/sup> <\/em>Agri Ibrahim Cecen University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Agri, T\u00fcrkiye
3<\/sup> <\/em>S\u00fcleyman Demirel University, Faculty of Pharmacy, Department of Biochemistry, Isparta, T\u00fcrkiye
4<\/sup> <\/em>Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, T\u00fcrkiye<\/td><\/tr>Abstract<\/strong>
Prostate cancer is among the most prevalent malignancies in men worldwide and remains a significant challenge in cancer therapy. Although numerous therapeutic options and drugs are currently used, the development of drug-resistant cancer cells and limited clinical efficacy highlight the need for new alternative therapeutic strategies [1]. N<\/em>-phenylacetamide is a scaffold associated with a wide range of biological activities, including anticancer, antifungal, antibacterial, antileishmanial, antidepressant, anticonvulsant, antimalarial, antiviral, analgesic, and antipyretic activities [2]. Moreover, numerous anticancer drugs containing an amide moiety in their structures are currently used in cancer therapy. In this study, a series of novel N<\/em>-(2-hydroxy-4-chlorophenyl)acetamide derivatives were designed and synthesized [3] as potential anticancer agents and evaluated for the cytotoxicity against non-neoplastic (PNT1A) and neoplastic (LNCaP and DU145) human prostate cell lines using colorimetric-based WST-1 cell viability test [4], with etoposide serving as the reference drug. To investigate the molecular basis of these effects, in silico<\/em> studies including molecular docking and ADME predictions were performed using Cresset Flare. The N<\/em>-phenylacetamide derivatives were docked into the androgen receptor obtained from the Protein Data Bank (PDB:5V8Q)<\/strong> to assess binding interactions, while computational ADME analysis provided insights into their pharmacokinetic properties and drug-likeness. In vitro<\/em> studies of the synthesized compounds demonstrated significant anticancer activity against prostate cancer. Furthermore, molecular docking studies revealed binding energies consistent with the in vitro<\/em> results. In conclusion, these N<\/em>-phenylacetamide derivatives may represent promising candidates for the treatment of prostate cancer.
Acknowledgments: <\/strong>We thank the Research Fund of Ankara University Grant No: TDK-2025-4460 for financial support of this study.<\/td><\/tr>References <\/strong>
[1] Litwin, M.S.; H.-J. Tan. The Diagnosis and Treatment of Prostate Cancer: A Review. JAMA<\/em>, 2017<\/strong>, 317<\/em>(24), 2532-2542.
[2] Rafiq, A.; Aslam, S.; Mohsin, N.A.; Ahmad, M. Synthetic Routes for the Development of Piperazine-Based Acetanilides and Their Medicinal Importance. Polycyclic Aromatic Compounds<\/em>, 2024<\/strong>, 44<\/em>(7), 4979-5007.
[3] Ertan, T.; Yildiz, I.; Ozkan, S.; Temiz-Arpaci, O.; Kaynak, F.; Yalcin, I.; Aki-Sener, E., Abbasoglu, U. Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro\/aminophenyl)benzamides and phenylacetamides as antimicrobial agents. Bioorg. Med. Chem<\/em>., 2007<\/strong>, 15<\/em>, 2032-2044.
[4] B\u00e1cskay, I.; Nemes, D.; Fenyvesi, F.; V\u00e1radi, J.; Vasv\u00e1ri, G.; Feh\u00e9r, P.; Vecserny\u00e9s, M.; Ujhelyi, Z. Role of cytotoxicity experiments in pharmaceutical development. Cytotoxicity<\/em>. 2017,<\/strong> 72539.<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n