{"id":1865,"date":"2026-05-06T18:21:54","date_gmt":"2026-05-06T16:21:54","guid":{"rendered":"https:\/\/sites.unica.it\/pe2026\/?p=1865"},"modified":"2026-05-06T18:35:03","modified_gmt":"2026-05-06T16:35:03","slug":"yushun-ihor","status":"publish","type":"post","link":"https:\/\/sites.unica.it\/pe2026\/2026\/05\/06\/yushun-ihor\/","title":{"rendered":"Yushun Ihor"},"content":{"rendered":"\n
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PE6 – Yushun Ihor<\/strong><\/p>\n\n\n\n

Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine<\/p>\n\n\n\n

e-mail<\/a> – LinkedIn<\/a><\/strong> –<\/strong> ORCID<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n

Synthesis and biological activity of thiazolidine derivatives with a pyrazoline fragment in molecules<\/strong><\/strong><\/td><\/tr>
1<\/sup><\/em> Yushyn Ihor
1<\/sup><\/em> Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine<\/td><\/tr>
Abstract<\/strong>
Pyrazoline\u2013thiazolidine hybrids are considered promising scaffolds because of their ability to interact with multiple biologically relevant targets, including kinases, inflammatory mediators, and nuclear receptors, which determines their broad pharmacological potential [1,2].
The dissertation focused on the synthesis of novel pyrazoline-containing thiazolidine and related derivatives as promising bioactive heterocycles. Efficient synthetic approaches, including [2+3]-cyclocondensation, Knoevenagel condensation, Claisen\u2013Schmidt reaction, and hetero<\/em>-Diels\u2013Alder reaction, enabled the preparation of structurally diverse pyrazolyl-substituted 4-thiazolidinones, thiazoles, and fused heterocyclic systems. Pyrazole-derived carbothioamides proved to be effective S,N<\/em>-binucleophilic reagents for obtaining new thiazolidinone derivatives, while reactions of isorhodanine with 3-methyl-1H<\/em>-pyrazol-5-amine afforded key intermediates for further functionalization. Unexpected transformations led to the formation of condensed pyrazolo[3,4-b<\/em>]thiazolo[5,4-e<\/em>]pyridines. Structures were confirmed by LC\u2013MS, NMR, and X-ray analysis.
Biological screening identified compounds with antitumor, antimicrobial, antifungal, and anti-inflammatory activities; some active derivatives also suggested possible PARP1\/2 inhibition. The most active compounds showed selective cytotoxicity toward Jurkat and MCF-7 cell lines, while selected fused heterocycles demonstrated activity against Gram-positive microorganisms.
Overall, 70 compounds were synthesized, and 20 hit compounds were identified.
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Figure 1. <\/strong>The most active synthesized molecules<\/td><\/tr>
References  <\/strong>
[1] Havrylyuk, D.; Roman, O.; Lesyk, R. Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole\/pyrazoline\u2013thiazolidine-based hybrids. Eur. J. Med. Chem. 2016, 113, 145\u2013166. https:\/\/doi.org\/10.1016\/j.ejmech.2016.02.030
[2] Elewa, S.I.; El-Farargy, A.F.; Nafie, M.S.; Mansour, E. Synthesis, and Cytotoxic Activity of Novel Pyrazoline-Thiazolidinone Derivatives with Molecular Docking Studies. Polycycl. Aromat. Compd. 2023, 43, 5807\u20135825. https:\/\/doi.org\/10.1080\/10406638.2022.2108074<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n

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PE6 – Yushun Ihor Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska St., 79010 Lviv, Ukraine e-mail – LinkedIn – ORCID Synthesis and biological activity of thiazolidine derivatives with […]<\/p>\n","protected":false},"author":9643,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1865","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/9643"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":2,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1865\/revisions"}],"predecessor-version":[{"id":1889,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1865\/revisions\/1889"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=1865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=1865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}