{"id":1701,"date":"2026-05-06T07:37:15","date_gmt":"2026-05-06T05:37:15","guid":{"rendered":"https:\/\/sites.unica.it\/pe2026\/?p=1701"},"modified":"2026-05-06T13:54:24","modified_gmt":"2026-05-06T11:54:24","slug":"marta-duran-martinez","status":"publish","type":"post","link":"https:\/\/sites.unica.it\/pe2026\/2026\/05\/06\/marta-duran-martinez\/","title":{"rendered":"Marta Duran Martinez"},"content":{"rendered":"\n
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OC20 – Marta Duran Martinez<\/strong><\/p>\n\n\n\n

Departamento de Qu\u00edmica Org\u00e1nica y Qu\u00edmica Inorg\u00e1nica, Universidad de Alcal\u00e1 (IRYCIS), RICORS-2040, Instituto de Investigaci\u00f3n Qu\u00edmica \u201cAndr\u00e9s M. Del R\u00edo\u201d (IQAR), INNOREN-CM, 28805-Alcal\u00e1 de Henares, Madrid, Spain<\/p>\n\n\n\n

e-mail<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n

New PROTAC approaches targeting the pseudokinase ILK<\/strong><\/td><\/tr>
Marta Dur\u00e1n Mart\u00ednez,1<\/sup> Jos\u00e9 Luis Ace\u00f1a,1<\/sup> Laura Calleros,2 <\/sup>Sergio de Frutos Garc\u00eda,2<\/sup> Diego Rodr\u00edguez Puyol,3<\/sup> Javier Garc\u00eda Mar\u00edn1<\/sup><\/em>

1<\/sup> <\/em>Departamento de Qu\u00edmica Org\u00e1nica y Qu\u00edmica Inorg\u00e1nica, Universidad de Alcal\u00e1 (IRYCIS), RICORS-2040, Instituto de Investigaci\u00f3n Qu\u00edmica \u201cAndr\u00e9s M. Del R\u00edo\u201d (IQAR), INNOREN-CM, 28805-Alcal\u00e1 de Henares, Madrid, Spain.
2 <\/sup><\/em>Departamento de Biolog\u00eda de Sistemas, RICORS 2040, Fundaci\u00f3n Renal I\u00f1igo \u00c1lvarez de Toledo, INNOREN-CM, Universidad de Alcal\u00e1 (IRYCIS), (IQAR), 28805-Alcal\u00e1 de Henares, Madrid, Spain.
3<\/sup> <\/em>Departamento de Medicina, Universidad de Alcal\u00e1, Servicio de Nefrolog\u00eda del Hospital Pr\u00edncipe de Asturias, Instituto Ramon y Cajal de Investigaci\u00f3n Sanitaria, RICORS 2040, Fundaci\u00f3n Renal I\u00f1igo \u00c1lvarez de Toledo, INNOREN-CM, Alcal\u00e1 de Henares, 28871 Madrid, Spain<\/td><\/tr>
Abstract<\/strong>
Pseudokinases represent an underexplored class of proteins with key regulatory roles in cell signaling. Notably, no proteolysis-targeting chimeras (PROTACs) have been reported to date for pseudokinases, highlighting a significant gap in the field of targeted protein degradation. Integrin-linked kinase (ILK), a well-characterized pseudokinase, is implicated in multiple pathological processes, including cancer and chronic kidney disease, and provides an attractive model to address this challenge and explore its potential as therapeutic target.
In this work, we describe the design and synthesis of a novel PROTAC aimed at inducing the selective degradation of ILK via the ubiquitin\u2013proteasome system. The proposed molecule combines an ILK-binding ligand with an E3 ligase recruiter through a rationally designed linker to promote proximity-driven ubiquitination and subsequent degradation of the target protein.

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Figure 1. ILK PROTAC design
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References  <\/strong>
[1] de Frutos, S., Luengo, A., Garcia-Jerez, A., Hatem-Vaquero, M., Griera. M., O’Valle, F., Rodriguez-Puyol, D., Calleros, L. Biochim. Biophys. Acta<\/em>, 2019<\/strong>, 1865(6):1284-1297.Author 1, A.; Author 2, B. Title of the chapter. In Book Title<\/em>, 2nd ed.; Editor 1, A., Editor 2, B., Eds.; Publisher: Publisher Location, Country, 2007; Volume 3, pp. 154\u2013196.
[2] Garcia-Mar\u00edn, J., Griera, M., Matamoros-Recio, A., de Frutos, S., Rodriguez-Puyol, M., Alajarin, R., Rodriguez-Puyol, D, Vaquero, J.J. ACS. Med. Chem. Lett.<\/em>, 2021, <\/strong>12(11):1656-1662.<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n

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OC20 – Marta Duran Martinez Departamento de Qu\u00edmica Org\u00e1nica y Qu\u00edmica Inorg\u00e1nica, Universidad de Alcal\u00e1 (IRYCIS), RICORS-2040, Instituto de Investigaci\u00f3n Qu\u00edmica \u201cAndr\u00e9s M. Del R\u00edo\u201d (IQAR), INNOREN-CM, 28805-Alcal\u00e1 de Henares, Madrid, Spain e-mail New PROTAC approaches […]<\/p>\n","protected":false},"author":9643,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1701","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/9643"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=1701"}],"version-history":[{"count":4,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1701\/revisions"}],"predecessor-version":[{"id":1804,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1701\/revisions\/1804"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=1701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=1701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=1701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}