{"id":1697,"date":"2026-05-06T07:31:27","date_gmt":"2026-05-06T05:31:27","guid":{"rendered":"https:\/\/sites.unica.it\/pe2026\/?p=1697"},"modified":"2026-05-06T13:51:19","modified_gmt":"2026-05-06T11:51:19","slug":"caterina-deruvo","status":"publish","type":"post","link":"https:\/\/sites.unica.it\/pe2026\/2026\/05\/06\/caterina-deruvo\/","title":{"rendered":"Caterina Deruvo"},"content":{"rendered":"\n
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OC16 – Caterina Deruvo<\/strong><\/p>\n\n\n\n

Universit\u00e0 degli Studi di Bari “A. Moro” – Dipartimento di Farmacia – Scienze del Farmaco<\/p>\n\n\n\n

e-mail<\/a><\/strong><\/p>\n<\/div><\/div>\n\n\n\n

Investigation of novel guaiacol-bearing molecules as multi-targeted directed ligands (MTDLs) against Alzheimer\u2019s disease-related targets<\/strong><\/strong><\/td><\/tr>
Deruvo Caterina1<\/sup>, Rosa Purgatorio1<\/sup>, Marianna Ranieri2<\/sup>, Modesto de Candia1<\/sup>, Marco Catto1<\/sup>, Orazio Nicolotti1<\/sup>, Grazia Tamma2<\/sup>, Cosimo D. Altomare1<\/sup>
<\/em>
1<\/sup> <\/em>Department of Pharmacy-Pharmaceutical Sciences, 2<\/sup> Department of Biosciences Biotechnologies and Environment, University of Bari Aldo Moro, Via E. Orabona 4, 70125, Bari,Italy<\/td><\/tr>
Abstract<\/strong>
Natural phenolic compounds such as eugenol, vanillin, curcumin and ferulic acid (FA) share a guaiacol fragment associated with antioxidant, anti-inflammatory, and neuroprotective activities, which make it a promising moiety of multitarget-directed ligands (MTDLs) for treating neurodegenerative disorders, including Alzheimer\u2019s disease (AD) [1]. In this study, the guaiacyl moiety was conjugated with indole and isatine cores, as well as tetrahydroazepino-indoles and chromenopyridines previously disclosed by some of us as inhibitors of \u03b2-amyloid aggregation, cholinesterases and monoamine oxidases [2,3]. Herein, the activities toward the AD-related targets of the newly synthesized guaiacyl derivatives 2-5 were investigated and compared with the ferulic acid ethyl ester 1.
The biological evaluation includes inhibition assays of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidases A and B (MAO A and B), \u03b2-amyloid aggregation studies, radical scavenging activity, and intracellular ROS measurements in cell models under oxidative stress conditions.<\/td><\/tr>
References  <\/strong>
[1] Li, D.; Rui, Y.; Guo, S.; Luan, F.; Liu, R.; Zeng, N. Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives. Life Sci. 2021, 284, 119921. https:\/\/doi.org\/10.1016\/j.lfs.2021.119921.
[2] Purgatorio, R.; De Candia, M.; De Palma, A.; De Santis, F.; Pisani, L.; Campagna, F.; Cellamare, S.; Altomare, C. D.; Catto, M. Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on \u03b2-Amyloid Aggregation and Neurotoxicity. Molecules 2018, 23 (7), 1544. https:\/\/doi.org\/10.3390\/molecules23071544.
[3] Purgatorio, R.; Kulikova, L. N.; Pisani, L.; Catto, M.; De Candia, M.; Carrieri, A.; Cellamare, S.; De Palma, A.; Beloglazkin, A. A.; Reza Raesi, G.; Voskressensky, L. G.; Altomare, C. D. Scouting around 1,2,3,4\u2010Tetrahydrochromeno[3,2\u2010c]Pyridin\u201010\u2010ones for Single\u2010 and Multitarget Ligands Directed towards Relevant Alzheimer\u2019s Targets. ChemMedChem 2020, 15 (20), 1947\u20131955. https:\/\/doi.org\/10.1002\/cmdc.202000468.<\/td><\/tr><\/tbody><\/table><\/div><\/figure>\n\n\n\n

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OC16 – Caterina Deruvo Universit\u00e0 degli Studi di Bari “A. Moro” – Dipartimento di Farmacia – Scienze del Farmaco e-mail Investigation of novel guaiacol-bearing molecules as multi-targeted directed ligands (MTDLs) against Alzheimer\u2019s disease-related targets Deruvo Caterina1, […]<\/p>\n","protected":false},"author":9643,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1697","post","type-post","status-publish","format-standard","hentry","category-senza-categoria"],"_links":{"self":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/users\/9643"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/comments?post=1697"}],"version-history":[{"count":3,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1697\/revisions"}],"predecessor-version":[{"id":1800,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/posts\/1697\/revisions\/1800"}],"wp:attachment":[{"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/media?parent=1697"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/categories?post=1697"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.unica.it\/pe2026\/wp-json\/wp\/v2\/tags?post=1697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}